Scandium-catalyzed allylboration of aldehydes as a practical method for highly diastereo- and enantioselective construction of homoallylic alcohols |
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| Authors: | Lachance Hugo Lu Xiaosong Gravel Michel Hall Dennis G |
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| Institution: | Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada. |
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| Abstract: | A general approach for the allylation of aldehydes using stable, air-tolerant camphor-based chiral allylboronates under Sc(OTf)3 catalysis is described. This practical methodology provides both syn and anti propionate units and other homoallylic alcohols with very high levels of diastereo- and enantioselectivity for several substrates, including functionalized aliphatic aldehydes useful toward the elaboration of complex natural products. |
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