Novel functionalized pyridine-containing DTPA-like ligand. Synthesis, computational studies and characterization of the corresponding Gd(III) complex |
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| Authors: | Artali Roberto Botta Mauro Cavallotti Camilla Giovenzana Giovanni B Palmisano Giovanni Sisti Massimo |
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| Institution: | Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Università degli Studi di Milano, Viale Abruzzi 42, 20131 Milan, Italy. roberto.artali@tiscali.it |
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| Abstract: | A novel pyridine-containing DTPA-like ligand, carrying additional hydroxymethyl groups on the pyridine side-arms, was synthesized in 5 steps. The corresponding Gd(III) complex, potentially useful as an MRI contrast agent, was prepared and characterized in detail by relaxometric methods and its structure modeled by computational methods. |
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