| 酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能 |
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| 引用本文： | 郝志峰,吴雅红,汪朝阳,黄卓亮,余坚,余林. 酰胺衍生寡聚DTPA钆配合物的合成、表征及弛豫性能[J]. 高等学校化学学报, 2012, 33(4): 663-667. DOI: 10.3969/j.issn.0251-0790.2012.04.000 |
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| 作者姓名： | 郝志峰 吴雅红 汪朝阳 黄卓亮 余坚 余林 |
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| 作者单位： | 1.广东工业大学轻工化工学院,广州,510006;2.华南师范大学化学与环境学院,广州,510006 |
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| 基金项目： | 国家自然科学基金,广东省自然科学基金 |
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| 摘 要： | 以寡聚二乙撑三胺-N,N′-二(乙酰苯胺)-N,N′,N-三乙酸([H3L]n)为配体,与GdCl3在二甲基甲酰胺-水混合溶剂中组装得到了寡聚金属螯合物.采用傅里叶变换红外光谱(FTIR)、元素分析、核磁共振氢谱(1H NMR)和热重及差热分析(TG-DTA)确定了寡聚金属螯合物的组成单元为[GdL(H2O)]·4H2O,即寡聚配体的每个链节与1个金属离子配位.采用反转恢复法测试了寡聚金属螯合物和小分子配合物Gd-DTPA(DTPA为二乙撑三胺五乙酸)的纵向弛豫时间T1,该寡聚金属螯合物体外弛豫率为8.526 mmol·L-1·s-1,与配合物Gd-DTPA的弛豫率(4.370 mmol.L-1.s-1)相比,弛豫性能明显提高.
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| 关 键 词： | 酰化聚合反应 寡聚配合物 Gd(Ⅲ)配合物 弛豫性能 |
| 收稿时间： | 2011-08-16 |
Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA |
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| HAO Zhi-Feng , WU Ya-Hong , WANG Zhao-Yang , HUANG Zhuo-Liang , YU Jian , YU Lin. Synthesis, Characterization and Relaxation Property of Oligomeric Gadolinium Complex Based on Amide Derivetives of DTPA[J]. Chemical Research In Chinese Universities, 2012, 33(4): 663-667. DOI: 10.3969/j.issn.0251-0790.2012.04.000 |
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| Authors: | HAO Zhi-Feng WU Ya-Hong WANG Zhao-Yang HUANG Zhuo-Liang YU Jian YU Lin |
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| Affiliation: | 1. Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;2. School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China |
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| Abstract: | An oligomeric complex was prepared via assembly reaction of oligomeric diethylenetriamine-N,N′-di(acetyl-p-aniline)-N,N′,N″-triacetic acid n with GdCl3 in DMF-H2O mixed solvent.The composition unit of the complex was confirmed to be [GdL(H2O)]·4H2O after characterized by Fourier transform infrared spectroscope(FTIR),elemental analysis,1H NMR,thermal gravimetric and differential thermal analysis(TG-DTA),which showed that every unit of the oligomeric ligand was coordinated to one metal ion.The longitudinal relaxivity time T1 of oligomeric Gd complex and Gd-DTPA(DTPA is diethylene triamine pentaacetic acid) were tested by inversion recovery.The results indicated that the relaxivity R1 of the oligomeric Gd complex was 8.526 mmol·L-1·s-1,which was greater than small molecular weight complex Gd-DTPA(4.370 mmol·L-1·s-1). |
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| Keywords: | Acylated polymerization Oligomeric complex Gd(Ⅲ) complex Relaxation property |
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