| 末端为磷酰胆碱基团的聚丁二酸丁二醇酯的酶促降解和热性能 |
| |
| 引用本文： | 张世平,王丹,党媛,史素青,宫永宽.末端为磷酰胆碱基团的聚丁二酸丁二醇酯的酶促降解和热性能[J].高等学校化学学报,2012,33(2):416-420. |
| |
| 作者姓名： | 张世平 王丹 党媛 史素青 宫永宽 |
| |
| 作者单位： | 合成与天然功能分子化学教育部重点实验室,西北大学化学与材料科学学院,西安710069 |
| |
| 基金项目： | 国家自然科学基金，陕西省教育厅基金 |
| |
| 摘 要： | 以聚丁二酸丁二醇酯(PBS)为参照,研究了酯酶Lipase AY30对亲水磷酰胆碱(PC)基团改性的聚丁二酸丁二醇酯(PBS-PC)的生物降解性能的影响.结果显示,在酯酶Lipase AY30作用下,21 d后PBS的质量损失仅为1.9%,而PBS-PC的质量损失了9.7%.相同条件下扣除各自水解引起的质量损失(PBS 1.4%和PBS-PC 6.5%)后,PC亲水基团的引入对聚合物的降解起到了促进作用.示差扫描量热(DSC)研究结果表明,改性后的聚合物熔融温度和熔融焓降低,玻璃化转变温度升高,表明PC端基的引入降低了PBS的结晶能力,非晶相结构的增多对聚合物降解有促进作用.因此PBS-PC有望作为一种新的具有良好生物降解性和生物相容性的高分子材料,应用于药物控释、基因治疗及组织工程等生物医用材料领域.
|
| 关 键 词： | 酯酶Lipase AY30 酶促降解 聚丁二酸丁二醇酯 磷酰胆碱 热性能 |
Enzymatic Biodegradation and Thermal Properties of Phosphorylcholine Functionalized Poly ( butylene succinate) |
| |
| ZHANG Shi-Ping
,
WANG Dan
,
DANG Yuan
,
SHI Su-Qing
,
GONG Yong-Kuan.Enzymatic Biodegradation and Thermal Properties of Phosphorylcholine Functionalized Poly ( butylene succinate)[J].Chemical Research In Chinese Universities,2012,33(2):416-420. |
| |
| Authors: | ZHANG Shi-Ping WANG Dan DANG Yuan SHI Su-Qing GONG Yong-Kuan |
| |
| Institution: | *(Key Laboratory of Synthetic and Natural Functional Molecule Chemistry,Ministry of Education, College of Chemistry & Materials Science,Northwest University,Xi’an 710069,China) |
| |
| Abstract: | Enzymatic degradation of poly(butylene succinate)(PBS) and phosphorylcholine functionalized poly(butylene succinate)(PBS-PC) were performed in the presence of lipase AY30.It was found that PBS-PC was effectively biodegraded by lipase AY30,and PBS was hardly degraded even after an experimental time scale of 21 d.By means of differential scanning calorimetry(DSC),thermal properties of PBS and PBS-PC were studied.The results show that the melting point(Tm) of PBS-PC is decreased and glass transition tempe-rature(Tg) is increased compared with unmodified PBS.PBS-PC may have potential applications in biological environments as new carriers for controlled drug release,gene therapy,and scaffold for tissue engineering systems. |
| |
| Keywords: | Lipase AY30 Enzymatic degradation Poly(butylene succinate) Phosphorylcholine Thermal stability |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
