| Gd3+与RGD共修饰量子点用于胰腺癌细胞的荧光及MR双模态成像 |
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| 引用本文： | 刘峰君,张兵波,宋歌,程英升.Gd3+与RGD共修饰量子点用于胰腺癌细胞的荧光及MR双模态成像[J].高等学校化学学报,2012,33(2):378-382. |
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| 作者姓名： | 刘峰君 张兵波 宋歌 程英升 |
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| 作者单位： | 1. 同济大学附属第十人民医院影像临床医学中心,上海,200072
2. 同济大学先进材料与纳米生物医学研究院,上海,200092 |
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| 基金项目： | 国家自然科学基金，上海市科委基础研究重点项目，同济大学青年优秀人才培养计划项目，苏州大学现代丝绸国家工程实验室基金 |
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| 摘 要： | 结合磁共振成像(MRI)和荧光成像技术,以钆离子(Gd3+)、量子点及精氨酸(R)-甘氨酸(G)-天冬氨酸(D)(RGD)多肽等为功能单元,采用纳米载体组装技术构建了MRI弛豫率/荧光效率高和靶向性强的Gd3+与RGD共修饰的量子点双模态纳米探针(QDs@Gd3+-RGD),并将其用于胰腺癌细胞的双模态成像.实验结果表明,QDs@Gd3+-RGD双模态纳米探针具有较高的弛豫率,且能对胰腺癌patu8988细胞进行荧光和T1-weighted MR成像.
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| 关 键 词： | 双模态成像 量子点 RGD 胰腺癌 |
Gd3+and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells |
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| LIU Feng-Jun
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ZHANG Bing-Bo
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SONG Ge
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CHENG Ying-Sheng.Gd3+and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells[J].Chemical Research In Chinese Universities,2012,33(2):378-382. |
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| Authors: | LIU Feng-Jun ZHANG Bing-Bo SONG Ge CHENG Ying-Sheng |
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| Institution: | 1*(1.Medical Imaging Center,the Tenth People’s Hospital of Tongji University,Shanghai 200072,China; 2.Institute for Advanced Materials & Nano Biomedicine,Tongji University,Shanghai 200092,China) |
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| Abstract: | Though early diagnosis of pancreatic cancer is difficult,it brings challenges and opportunities to the molecular imaging.The existing diagnostic imaging technologies are limited as a result of single functiona-lity,making it difficult for accurate diagnosis.In this work,magnetic resonance image(MRI) and fluorescence imaging were combined by several key contrast agents including gadolinium ion,quantum dots(QDs) and arginine(R)-glycine(G)-D-aspartic acid(D)(RGD) for high relaxation rate,strong fluorescent emission and good targeting.The integrated dual-modality QDs@Gd3+-RGD nanoprobes were used for dual-modality imaging of pancreatic cancer cells.TEM and dynamic light scattering(DLS) results indicate complete dispersion of QDs@Gd3+-RGD nanoprobes in water.In vitro relaxivity measurement shows high relaxation rate of QDs@Gd3+-RGD nanoprobes.Their r1 and r2 are 7.6 and 9.5 L·mmol-1·s-1,respectively.Fluorescent and MR dual-modality imaging suggest the prepared QDs@Gd3+-RGD nanoprobes can sever as both fluorescent and MR imaging of patu8988 pancreatic cancer cells. |
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| Keywords: | Dual-modality imaging Quantum dots Arginine(R)-glycine(G)-D-aspartic acid(D)(RGD) Pancreatic cancer |
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