Acid—base equilibria in the mixed solvent 80% dimethyl sulfoxide—20% water : Part I. definition of ph scale and determination of pk values of aliphatic monocarboxylic acids |
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Authors: | Milka Georgieva Georgi Velinov Omortag Budevsky |
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Affiliation: | Institute of Chemical Technology, Darvenitza,SofiaBulgaria;Faculty of Pharmacy, Academy of Medicine, Ekz. Josif 15, SofiaBulgaria |
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Abstract: | The acid—base equilibria in the mixed solvent, 80% dimethyl sulfoxide—water, have been investigated by potentiometric measurements with a glass—silver—silver chloride electrode couple. The response of the glass electrode is quick and reproducible over the whole pH scale. The autoprotolysis constant (itKSH) of the mixed solvent has been determined; the value obtained, pKSH = 18.40, agrees well with reported data. The pKa values of the following aliphatic monocarboxylic acids are reported: formic, acetic, propionic, n-butyric, iso-butyric, n-valeric, iso-valeric, capric, pentadecanoic, stearic, monochloroacetic. The mixed solvent offers better titration conditions than water for the determination of these acids. |
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