金纳米团簇功能化及其在生物医学中的应用

对单分子层保护的金纳米团簇(Au-MPCs)进行化学修饰,可制成多元单层修饰的金纳米团簇（Au-MMPCs）。常用的修饰方法为配体交换法,这种方法用带有生物活性基团的巯基化合物或二硫化合物取代Au-MPCs表面的配体分子,形成多元单层修饰的金纳米团簇。巯基化合物或二硫化合物中的生物活性基团可使所制备Au-MMPCs与蛋白质、核酸或细胞膜等作用,使Au-MMPCs具有相应的生物活性,从而能广泛应用于细胞转染、药物传输、酶活性调控等生物医学领域。本文介绍了用Brust-Schiffrin法制备Au-MMPCs的机理及影响因素,基于Au-MMPCs的方法及相关机理,综述了Au-MMPCs在生物医学中的应用。

Functional Gold Clusters and Their Applications in Biomedicine

Mixed monolayer protected gold clusters(Au-MMPCs) can be prepared by modifying the monolayer protected gold clusters(Au-MPCs) with various bioactive thiol or disulfide ligands.The interaction of these Au-MMPCs with biomaterials,such as proteins,nucleic acids,and cell membranes,make them useful in cell transfection,drug delivery and enzyme activity regulation.In this paper,the factors that affect the synthesis of gold clusters in Brust-Schiffrin reaction are introduced.The strategies and mechanisms of preparation of mixed monolayer protected gold clusters(Au-MMPCs) based on the Brust-Schiffrin reaction are summarized,in which the ligand exchange reaction are described in detail.The applications of Au-MMPCs in biomedicine are reviewed.