Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe |
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| Authors: | Ghosh Krishna Kanta Ha Hyung-Ho Kang Nam-Young Chandran Yogeswari Chang Young-Tae |
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| Institution: | Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543 Singapore, Singapore. |
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| Abstract: | We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8. |
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