Hyperbranched polymers versus dendrimers containing a carbosilane framework and terminal ammonium groups as antimicrobial agents |
| |
Authors: | Ortega Paula Macarena Cobaleda Beatriz Hernández-Ros Jose Manuel Fuentes-Paniagua Elena Sánchez-Nieves Javier Tarazona Ma Pilar Copa-Patiño Jose Luis Soliveri Juan de la Mata Fco Javier Gómez Rafael |
| |
Institution: | Departamento de Química Inorgánica, Universidad de Alcalá, Campus Universitario, Edificio de Farmacia, E-28871, Alcalá de Henares, Spain. |
| |
Abstract: | A new family of amine- and ammonium-terminated hyperbranched polycarbosilanes (PCS) and dendrimers has been synthesized. The functionalization of a polycarbosilane matrix was carried out with peripheral allyl groups by two strategies in the case of PCS: 1) hydrosilylation of allyl amines with PCS containing terminal Si-H bonds, or 2) hydrosilylation of PCS-allyl with an aminosilane. Dendrimers with terminal amine groups were synthesized by hydrosilylation of allydimethylamine. Quaternized systems with MeI are soluble and stable in water or other protic solvent. The antibacterial properties of the ammonium-terminated hyperbranched polycarbosilanes and dendrimers have been evaluated showing that they act as potent biocides against Gram-positive and Gram-negative bacterial strains. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|