Synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate |
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| Authors: | Giner José-Luis Ferris William V |
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| Affiliation: | Department of Chemistry, State University of New York-ESF, Syracuse, New York 13210, USA. jlginer@syr.edu |
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| Abstract: | [reaction: see text] The synthesis of 2-C-methyl-D-erythritol 2,4-cyclopyrophosphate, a biochemical intermediate in the deoxyxylulose pathway of isoprenoid biosynthesis, was accomplished in four steps. Bisphosphorylation of 2-C-methyl-D-erythritol 1,3-diacetate, followed by carbodiimide cyclization and deprotection, led to the title compound in 42% overall yield. |
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