Tuning rate of the bergman cyclization of benzannelated enediynes with ortho substituents |
| |
| Authors: | Alabugin Igor V Manoharan Mariappan Kovalenko Serguei V |
| |
| Affiliation: | Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA. alabugin@chem.fsu.edu |
| |
| Abstract: | [reaction: see text] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
