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| 基于5-孟氧基-3-溴-2(5H)-呋喃酮的环丙烷合成方法研究:碳亲核试剂启动的不对称串联反应 | |
| 引用本文： | 郭金波,张淅芸,陈庆华.基于5-孟氧基-3-溴-2(5H)-呋喃酮的环丙烷合成方法研究:碳亲核试剂启动的不对称串联反应[J].化学学报,2006,64(19):2008-2014. |
| 作者姓名： | 郭金波 张淅芸 陈庆华 |
| 作者单位： | 1. 洛阳师范学院化学系,洛阳,471022 2. 北京师范大学化学系,北京,100875 3. 洛阳师范学院化学系,洛阳,471022;北京师范大学化学系,北京,100875 |
| 摘 要： | 研究碳亲核试剂(2a～2e)与手性合成砌块, 5-孟氧基-3-溴-2(5H)-呋喃酮的不对称串联反应, 分别得到不同结构的光学活性化合物3a～3d, 4, 5和6. 通过X射线晶体分析确认了它们的立体化学结构. |
| 关 键 词： | 不对称串联反应 碳-碳键形成 光学活性 晶体结构 |
| 收稿时间： | 12 24 2005 12:00AM |
| 修稿时间： | 2005-12-242006-06-01 |
Study of the Synthetic Method of Cyclopropane Derivatives Based on 3-Bromo-2,5-dihydro-5-menthyloxyfuran-2-one: Asymmetric Tandem Reaction Starting by Carbon Nucleophile |
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| GUO,Jin-Bo,ZHANG,Xi-Yun,CHEN,Qing-Hua.Study of the Synthetic Method of Cyclopropane Derivatives Based on 3-Bromo-2,5-dihydro-5-menthyloxyfuran-2-one: Asymmetric Tandem Reaction Starting by Carbon Nucleophile[J].Acta Chimica Sinica,2006,64(19):2008-2014. | |
| Authors: | GUO Jin-Bo ZHANG Xi-Yun CHEN Qing-Hua |
| Institution: | a Department of Chemistry, Luoyang Normal College, Luoyang 471022;b Department of Chemistry, Beijing Normal University, Beijing 100875 |
| Abstract: | The structurally different chiral compounds 3a～3d, 4, 5 and 6 with newly formed stereogenic centers were obtained via the tandem asymmetric Michael addition and internal nucleophilic substitution reaction of 3-bromo-2,5-dihydro-5-menthyloxyfuran-2-one with different carbon nucleophiles. The chemical structures of these complicated compounds were determined by analytical and spectroscopic data. The proposed structures were confirmed by the X-ray crystallographic analysis of 3a (S), 5 and 6. |
| Keywords: | tandem asymmetric reaction carbon-carbon bond formation optical activity crystal structure |
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