Synthese von Glycerylätherphosphatiden 1. Mitteilung Herstellung von 1-O-Octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholin1 (‘Platelet Activating Factor’), des Enantiomeren sowie einiger analoger Verbindungen

Synthesis of Glyceryletherphosphatides, 1st Communication, Preparation of 1-O-Octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (‘Platelet Activating Factor’), of its Enantiomer and of Some Analogous Compounds Several synthetic sequences for the preparation of ‘Platelet Activating Factor’ ( 1a ), for the corresponding enantiomeric compound ( 1′a ) as well as for the ‘Lyso-compounds’ ( 1b and 1′b ) are described. The use of glycerolacetonide 2′a (from D-Mannitol) for the preparation of 1′a and la is presented together with the synthesis of some analogues of 1′a and 1a . Structural assignment and optical purity of the compounds prepared are confirmed.