Synthese von 1, 2-annelierten 1, 4-Benzodiazepinen und 4, 1-Benzoxazepinen |
| |
Authors: | Werner Müller Urs Stauss |
| |
Abstract: | The syntheses of 1, 2-annelated 1, 4-benzodiazepines (IV, Y = N) and 4, 1-benzoxazepines (IV, Y = 0) are described (Scheme 1). The key step is a nucleophilic aromatic substitution of 2-substituted piperazines (II, Z = N? CH3), piperidines (II, Z = CH2) or pyrrolidines (II, Z= (CH2)0) with activated aryl halides (I). |
| |
Keywords: | |
|
|