Opposite CD curves in chromophoric derivatives of 3-substituted 5-and 6-membered cyclic amines

Absolute configuration was assigned to 3-isopropylpyrrolidine by chemical correlation with R-3-isopropylsuccinic acid. The comparison between CD curves of 3-substituted piperidines, morpholines and pyrrolidine having the same chirality shows that the chiroptical properties of these five and six-membered cyclic amine derivatives are opposite.