Abstract: | Analogues of apomorphine (1) having the catechol moiety replaced by pyrrole (→ 10 , 18 ), pyrazole (→ 12 ), isoxazole (→ 13 , 14 ), thiazole (→ 16 ) and thiadiazole (→ 20 ) ring systems have been synthesized from the key intermediate ketone 6 . |