Nitrogen bridgehead compounds. Part 19. Synthesis of polymethylenepyrimidin-4-ones |
| |
| Authors: | J zsef K k si,Gy rgy Sz sz,Istv n Hermecz,Zolt n M sz ros,Marianne Cs kv ri-Pongor,G bor T th |
| |
| Affiliation: | József Kökösi,György Szász,István Hermecz,Zoltán Mészáros,Marianne Csákvári-Pongor,Gábor Tóth |
| |
| Abstract: | Reaction of five-, six-, seven-, and eight-membered cyclic amidines ( 1 n = 0-3) with diethyl ethoxy-methylenemalonate ( 2 ) yields isomeric 2,3-polymethylene-4(3H]- and 1,2-polymethytlene-4(1H)-pyrimidinones ( 3 and 4 ) respectively, n = 0-3). With 2-aminopyrroline the isomer ratio was dependent upon the reaction conditions. The structure of the isomers 3 and 4 was studied by uv, ir and 1H-nmr spectroscopy. Both isomers contain an active methylene group which can be deuterated. Deuteration was investigated with 1H-nmr spectroscopy. |
| |
| Keywords: | |
|
|
