| Abstract: | The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated. Except in the case of the reaction of 2-propylpyrazine 1-oxide with acetic anhydride, chlorination or acetoxylation occurred on the pyrazine ring in all cases; moreover, these reactions occurred preferentially at the position poorest in π-electron density. The N-oxidation and the successive chlorination of monochloro-phenylpyrazines were also investigated, and the structures of the products were confirmed. |
