Normal Phase High Performance Liquid Chromatography of Some Prostaglandin B1 Derivatives |
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Abstract: | Abstract 15-Keto-13, 14-trans-prostaglandin B1 methyl ester, 13,14-trans-prostaglandin B1 methyl ester, 13,14-cis-prostaglandin B1 methyl ester, 13,14-dihydro-prostaglandin B1 methyl ester and 13,14-dehydro-prostaglandin B1 are organic intermediates used in the synthesis of prostaglandin Bx, a polymeric derivative of 15-keto-prostaglandin B1 methyl ester. PGBx has been shown to protect laboratory animals against cardiogenic shock, cerebral ischemia and hypoxia. A normal phase, high performance liquid chromatographic analysis is presented which permits the identification and quantitation of these PGB1 intermediates. |
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