Quantitative Analysis of Adulterants in Illicit Heroin Samples via Reversed Phase HPLC

Abstract

Methodology is presented using reversed phase liquid chromatography for the simultaneous quantitation of phenobarbital, methaqualone, phenolphthalein, nicotinamide, and N-phenyl-2-naphthylamine in heroin samples. A Partisil 5 ODS-3 column was used with a gradient system using methanol and a sodium dodecylsulfate-phosphate buffer.