Asymmetric construction of quaternary carbon stereocenter by Pd-catalyzed intramolecular alpha-arylation |
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| Authors: | Arao Takafumi Kondo Kazuhiro Aoyama Toyohiko |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Nagoya City University. |
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| Abstract: | The catalyst comprised of Pd(OAc)(2) and H(8)-BINAP provides good reaction conversions for a catalytic enantioselective intramolecular alpha-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide to form the quaternary carbon with up to 68% enantioselectivity. |
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