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Synthesis of Distamycin Analogs and Their Interactions with Calf Thymus DNA |
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| Authors: | Jun‐Hua Xiao Gu Yuan Wei‐Qiang Huang Wei‐Hong Du Bao‐Huai Wang Zhi‐Fen Li |
| Abstract: | Two distamycin analogs (PyPyPy‐γ‐Dp and PyPyPyPy‐γ‐Dp) were synthesized by a haloform reaction and the DCC/HOBT coupling reaction in a ample and fast way without amino protection. By using calf thymus DNA, the interaction between the analogs and DNA duplex was studied by CD, and ITC. |
| Keywords: | Synthesis distamycin analogs calf thymus DNA molecular recognition |