Synthesis of new 5‐substitutedbenzo[b]thiophene derivatives

Previous works of our group have dealt with the synthesis of 1‐(aryl)‐3‐4‐(aryl)piperazin‐1‐yl]propane derivatives in the search for new and efficient antidepressants with a dual mode of action: serotonin reuptake inhibition and 5‐HT_1A receptor afinity 1‐4]. From these studies we concluded that the 3‐4‐(aryl)piperazin‐1‐yl]‐1‐(benzob]thiophen‐3‐yl)propane derivatives led to the best results. The continuation of this research project required the preparation of some new 3‐acyl‐5‐substituted benzob]thiophenes with a wide variety of substituents at the 5 position, ranging from nitro to hydroxyl derivatives. To obtain these derivatives we acylated the corresponding 5‐substituted benzob]thiophenes when it was possible.