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Synthesis of Nitrated Analogs of Distamycin and their DNA Cleaving and Protecting Activities under UV Irradiation |
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| Authors: | Junhua Xiao Gu Yuarf Weiqiang Huang John H K Lum K‐L Daniel Lee Albert S C Chan |
| Abstract: | Two nitrated analogs of distamycin were synthesized by a novel haloform reaction and the DCC/HOBT coupling reaction in a convenient and effective way with out amino group protection. Our results have demonstrated that these polyamides show DNA cleaving activity under long UV (LUV 365 nm) irradiation. Furthermore, it is an unexpected discovery that these analogs can prevent DNA dam age under short UV (SUV 302 nm). |
| Keywords: | Analogs of distamycin DNA cleaving and protecting activities |