Synthesis and biological study of 6‐polyhydroxyalkylpteridines |
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| Authors: | M Dolores Lpez M Luisa Quijano Adolfo Snchez Manuel Nogueras John N Low |
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| Institution: | M. Dolores López,M. Luisa Quijano,Adolfo Sánchez,Manuel Nogueras,John N. Low |
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| Abstract: | 6‐Polyhydroxyalkylpteridines are synthesised by oxidation of the corresponding pyrano3,2‐g]pteridines, the latter ones having been obtained by condensation between 5,6‐diaminopyrimidines 1a,b and phenylhydra‐zones 2a‐e . The relative configuration at the chiral centers of the pyrano3,2‐g]pteridines has been determined by nmr study and X‐ray analysis. The anti‐AIDS activity of several of these compounds has been tested. |
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