PROFLAVINE-SENSITIZED PHOTOOXIDATION OF METHIONINE |
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| Authors: | GIULIO JORI GIULIO CAUZZO |
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| Affiliation: | Institute of Organic Chemistry, University of Padova, Padova, National Center of the Macromolecules of the 'Consiglio Nazionale delle Ricerche', Section VIII, Padova, Italy;Institute of Physical Chemistry, University of Padova, Padova, Laboratory of Photochemistry and High Energy Radiations of the 'Consiglio Nazionale delle Ricerche', Bologna, Italy |
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| Abstract: | Abstract— A study was made of the kinetics of the proflavine-sensitized photooxidation of methionine to methionine sulfoxide. The reaction is inhibited by the paramagnetic ions Cu2+ and Mn2+, which suggests that the triplet state of the sensitizer is an intermediate. A mechanism is proposed in which methionine reacts with the first singlet state of oxygen, produced by energy transfer from the triplet sensitizer. The decrease in the rate of photooxidation with increasing proflavine concentration is ascribed to self-quenching of the excited singlet state of the dye. |
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