Cupric superoxo-mediated intermolecular C-H activation chemistry |
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| Authors: | Peterson Ryan L Himes Richard A Kotani Hiroaki Suenobu Tomoyoshi Tian Li Siegler Maxime A Solomon Edward I Fukuzumi Shunichi Karlin Kenneth D |
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| Institution: | Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States. |
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| Abstract: | The new cupric superoxo complex LCu(II)(O(2)(?-))](+), which possesses particularly strong O-O and Cu-O bonding, is capable of intermolecular C-H activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases. |
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