Development of Functional Composite Cu(II)-Polyoxometalate/PLA with Antimicrobial Properties |
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| Authors: | Ella Duvanova Illia Krasnou Andres Krumme Valdek Mikli Serhii Radio Georgiy M Rozantsev Yevgen Karpichev |
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| Institution: | 1.Department of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 12618 Tallinn, Estonia;2.Research Laboratory “Chemistry of Polyoxometalates and Complex Oxide Systems”, Vasyl’ Stus Donetsk National University, 21027 Vinnytsia, Ukraine; (S.R.); (G.M.R.);3.Department of Materials and Environmental Technology, Tallinn University of Technology (TalTech), 19086 Tallinn, Estonia; (I.K.); (A.K.); (V.M.) |
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| Abstract: | Novel composite self-disinfecting films of polylactic acid (PLA) filled with nanosized particles of double sodium–copper(II) paratungstate B Na2Cu3(CuOH)2W12O40(OH)2]·32H2O (POM) were developed. The solvent casting (POM/PLA film) and solvent-free melt extrusion methods (Extr. POM/PLA film) were applied for film preparation. The copper (II) ion release to water from both types of the films after 10 days at different temperatures demonstrated that the PLA matrix acts as a diffusion barrier, and the resulting concentration of released copper in water at room temperature remained low, at 0.79% for POM/PLA film and 0.51% for Extr. POM/PLA film. The POM-containing films reveals a significant inhibitory effect against E. coli ATCC 25922 in the agar diffusion test. The numbers of CFUs in washes of the films after incubation for 24 h were found to be 3.6 log CFU mL–1 (POM/PLA film) and 4.1 log CFU mL–1 (Extr. POM/PLA film). The films combine the antibacterial properties of POM and a bio-based polymer matrix, which makes them a prospective coating material for applications in hospital indoor environments. Excellent thermal stability of POM gives a technological advantage for industrial manufacturing to allow the processing of novel composite material in the solvent free (molten) state. |
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| Keywords: | polyoxometalate copper(II) paratungstate B poly(lactic acid) antimicrobial surfaces composite films |
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