A simulation approach to cost-effectiveness and cost-benefit calculations of screening for the early detection of disease |
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| Institution: | 1. University of Alabama at Birmingham, 1665 University Blvd., Birmingham, AL US 35294, United States;2. Arizona State University, 500 N. 3rd Street, Phoenix, AZ 85004, United States;3. University of Texas at Austin, 103 W. 24th Street, Austin, TX 78712, United States;4. University of California, San Diego, 9500 Gilman Drive, 0628, La Jolla, CA 92093-0628, United States;1. Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands;2. Department of Industrial Engineering and Innovation Sciences, Eindhoven University of Technology, Eindhoven, The Netherlands |
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| Abstract: | The computer simulation program Miscan, developed for analysis, prediction and optimization of screening for early detection of disease, has been extended to enable full cost-effectiveness and cost-benefit calculations. The user specifies which of the available cost- and effectiveness-items are to be used and can choose the valuation per unit for each item. The program computes the volume of each item for scenarios with and without screening, and calculates the costs and effectiveness of the simulated screening policy. The program allows for discounting and present value computations, for scale effects, and for quality adjustment of life years for age and disease stage. The use of the program is illustrated with a model of cervical cancer screening that was based on data from the pilot project in the Netherlands. Two screening policies are compared for several discount rates, and for several exchange rates between costs and health effects. |
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