Synthesis,antifungal and insecticidal activity of novel [1,2,4]triazolo[4,3-a]pyridine derivatives containing a sulfide substructure |
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| Authors: | Fang-Zhou Xu Jia-Hui Shao Yun-Ying Zhu Li-Wei Liu Yong-Hui Zhao Wei-Li Shan Yan-Yan Wang Jian Wu Song Yang Wei Xue |
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| Affiliation: | 1.State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals,Guizhou University,Guiyang,People’s Republic of China;2.College of Life Science,Zaozhuang University,Zaozhuang,People’s Republic of China;3.School of Chemical Engineering,Guizhou Institute of Technology,Guiyang,People’s Republic of China;4.Institute for the Control of Agrochemicals,Ministry of Agriculture,Beijing,People’s Republic of China |
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| Abstract: | A series of [1,2,4]triazolo[4,3-a]pyridine derivatives bearing a sulfide substructure was designed, synthesized and characterized via 1H·NMR, 13C·NMR, IR and elemental analyses. Bioassay Results indicated some of the derivatives displayed good fungicidal activity on Rhizoctonia cerealis, moderated insecticidal activity against Plutella xylostella and good insecticidal activity on Helicoverpa armigera. The inhibitory effects of compounds 4g and 4u against Rhizotonia cerealis were 70.9% at 50 μg mL?1; the IC50 values of compounds 4d and 4s against Plutella xylostella were 43.87 and 50.75 μg mL?1, respectively. And the IC50 values of compounds 4d, 4q, and 4s on Helicoverpa armigera were 58.3, 77.14 and 65.31 μg mL?1, respectively, which were better than that of commercial chlorpyrifos (103.77 μg mL?1). |
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