Voltammetric determination of mesalazine in pharmaceutical preparations and biological samples using boron-doped diamond electrode |
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Authors: | Michaela ?těpánková Renáta ?ele?ovská Lenka Janíková Jaromíra Chýlková |
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Institution: | 1.Institute of Environmental and Chemical Engineering,University of Pardubice,Pardubice,Czech Republic |
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Abstract: | Voltammetric method for the determination of non-steroidal anti-inflammatory drug mesalazine (5-ASA) is presented for the first time using boron-doped diamond electrode (BDDE). 5-ASA provides one well-developed SWV oxidation peak at about ?900 mV (vs. saturated silver/silver chloride reference electrode) on BDDE. Britton-Robinson buffer (pH 7.0) was chosen as an optimal supporting electrolyte for the determination of 5-ASA using square wave voltammetry (SWV). Parameters of SWV were developed and low limit of detection (7.0 × 10?7 mol L?1) was reached. In addition, relative standard deviation of repeated measurements (c 5-ASA = 5 × 10?5 mol L?1, RSDM = 2.7%) and relative standard deviation of repeated determinations (RSDD < 1.5%) were calculated and confirm obtained good results. Applicability of the proposed method was verified by an analysis of a pharmaceutical preparation and spiked human urine. |
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