Brønsted Base Catalyzed One‐Pot Synthesis of Stereodefined Six‐Member Carbocycles Featuring Transient Trienolates and a Key Intramolecular 1,6‐Addition |
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Authors: | Olatz Olaizola Igor Iriarte Giovanna Zanella Enrique Gmez‐Bengoa Iaki Ganboa Mikel Oiarbide Claudio Palomo |
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Institution: | Olatz Olaizola,Igor Iriarte,Giovanna Zanella,Enrique Gómez‐Bengoa,Iñaki Ganboa,Mikel Oiarbide,Claudio Palomo |
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Abstract: | A catalyst‐driven one‐pot reaction sequence is developed for the enantio‐ and diastereoselective synthesis of tetrasubstituted cyclohexenes from simple unsaturated ketones or thioesters. The method involves a tertiary amine/squaramide‐catalyzed α‐selective addition of transiently generated trienolates to nitroolefins, subsequent base‐catalyzed double bond isomerization, and an intramolecular (vinylogous) 1,6‐addition reaction, a rare key carbocyclization step that proceeded with essentially perfect stereocontrol. |
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Keywords: | Brø nsted-Basen 1 6-Konjugierte Additionen Organokatalyse Synthesemethoden Trienolate |
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