|
|||||
|
|
Concerted Nucleophilic Aromatic Substitution Reactions |
|
| Authors: | Simon Rohrbach Andrew J. Smith Jia Hao Pang Darren L. Poole Tell Tuttle Shunsuke Chiba John A. Murphy |
| Abstract: | Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cSNAr) rather than classical, two‐step, SNAr mechanisms. Whereas traditional SNAr reactions require substantial activation of the aromatic ring by electron‐withdrawing substituents, such activating groups are not mandatory in the concerted pathways. |
| Keywords: | concerted reactions cSNAr mechanism Meisenheimer complex nucleophilic aromatic substitution |