Abstract: | In this paper, we propose a new fast level set model of multi‐atlas labels fusion for 3D magnetic resonance imaging (MRI) tissues segmentation. The proposed model is aimed at segmenting regions of interest in MR images, especially the tissues such as the amygdala, the caudate, the hippocampus, the pallidum, the putamen, and the thalamus. We first define a new energy functional by taking full advantage of an image data term, a length term, and a label fusion term. Different from using the region‐scalable fitting image data term and length term directly, we define a new image data term and a new length term, which is also incorporated with an edge detect function. By introducing a spatially weight function into the label fusion term, segmentation sensitivity to warped images can be largely improved. Furthermore, the special structure of the new energy functional ensures the application of the split Bregman method, which is a significant highlight and can improve segmentation efficiency of the proposed model. Because of these promotions, several good characters, such as accuracy, efficiency, and robustness have been exhibited in experimental results. Quantitative and qualitative comparisons with other methods have demonstrated the superior advantages of the proposed model. |