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Copper‐Catalyzed Electrophilic Cyclization of N‐Propargylamines with Sodium Sulfinate for the Synthesis of 3‐Sulfonated Quinolines |
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| Authors: | Ling Li Xing‐Guo Zhang Bo‐Lun Hu Xiao‐Hong Zhang |
| Abstract: | A convenient and effective protocol for the synthesis of 3‐sulfonated quinolines via copper‐catalyzed electrophilic cyclization of N‐propargylamines has been developed, in which cheap and stable sodium sulfinates were utilized as green sulfonylation reagents. This cascade transformation involves radical addition, cyclization and dehydrogenative aromatization processes in a one‐pot reaction under mild conditions. |
| Keywords: | 3-Sulfonated Quinolines Copper Catalysis Electrophilic Cyclization N-Propargylamines Sodium Sulfinate |