| Synthesis and Antitumor Activity of 7-Substituted Derivatives of Homocamptothecin |
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| 作者姓名： | Zhen Yuan MIAO Wan Nian ZHANG Jian Zhong YAO Chun Quan SHENG Yun Long SONG Hui XU Min ZHANG Jing ZHANG |
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| 作者单位： | Zhen Yuan MIAO，Wan Nian ZHANG，Jian Zhong YAO，Chun Quan SHENG，Yun Long SONG，Hui XU，Min ZHANG，Jing ZHANG School of Pharmacy，Second Military Medical University，Shanghai 200433 |
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| 摘 要： | Camptotecin is the parent of an important class of anticancer agents which, can selectively poison the ubiquitous nuclear enzyme topoisomerase. Water soluble camptothecin analogues such as topotecan and irinotecan are already approved for clinical uses in…
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| 关 键 词： | 合成 抗癌活性 同喜树碱 取代反应 |
| 收稿时间： | 2005-12-01 |
Synthesis and Antitumor Activity of 7-Substituted Derivatives of Homocamptothecin |
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| Zhen Yuan MIAO Wan Nian ZHANG Jian Zhong YAO Chun Quan SHENG Yun Long SONG Hui XU Min ZHANG Jing ZHANG.Synthesis and Antitumor Activity of 7-Substituted Derivatives of Homocamptothecin[J].Chinese Chemical Letters,2006,17(6):720-722. |
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| Authors: | Zhen Yuan MIAO Wan Nian ZHANG Jian Zhong YAO Chun Quan SHENG Yun Long SONG Hui XU Min ZHANG Jing ZHANG |
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| Abstract: | Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard MTT method. The results showed that some of the homocamptothecin derivatives had higher antitumor activity than topotecan. |
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| Keywords: | Antitumor activity homocamptothecin synthesis |
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