Synthesis and in vitro-Anti-hepatitis B Virus Activities of Several Ethyl 5-Hydroxy-1H-indole-3-carboxylates |
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Authors: | ZHAO Chun-shen ZHAO Yan-fang CHAI Hui-fang GONG Ping |
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Institution: | Liaoning Province Key Laboratory of Innovative Medicine Research and Design, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China |
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Abstract: | A series of ethyl 5-hydroxyindole-3-carboxylates 6a-10r was designed and synthesized. The structures of all the compounds were confirmed by IR, 1H NMR, and MS and their anti-hepatitis B virus(HBV) activities were evaluated in 2.2.15 cells. Among them, compound 7g {ethyl 5-hydroxy-2-(3-methoxyphenylsulfinyl) methyl] -1-methyl-4- (4-methylpiperazin-1-yl)methyl]-1H-indole-3-carboxylate} displays a significant anti-HBV activity, which is more potent than the positive control lamivudine. |
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Keywords: | Ethyl 5-hydroxy-1H-indole-3-carboxylates Synthesis Anti-hepatitis B virus activity |
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