4-(Isoindolin-5-yl)amino-4-oxobutyryl-β-alkoxyphenyl-β-alanines, new RGDF mimetics. Synthesis, affinity to fibrinogen receptors, antiaggregatory properties, and their correlation with the hydrophobicity |
| |
| Authors: | S. A. Andronati A. A. Krys’ko B. M. Chugunov T. A. Kabanova A. G. Artemenko |
| |
| Affiliation: | (1) Bogatskii Physicochemical Institute, National Academy of Sciences of Ukraine, Odessa, 6508, Ukraine |
| |
| Abstract: | A new series of RGDF mimetics, derivatives of 4-(isoindolin-5-yl)amino-4-oxobutanoic acid, was synthesized. The compounds obtained inhibit efficiently the thrombocytes aggregation in experiments in vitro; their biological targets are fibrinogen receptors. The antiaggregatory activity and the affinity correlate with the hydrophobicity of the compounds. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
