Syntheses,spectral property,and antimicrobial activities of 6‐α‐amino dibenzo [d,f][1,3,2]dioxaphosphepin 6‐oxides

Diethyl α‐aminophosphonates ( 4 ) were prepared in excellent yield from three‐component reaction of aldehydes ( 1 ), amines ( 2 ), and triethylphosphite ( 3 ) under solvent‐free conditions in the presence of ceric ammonium nitrate (CAN) and were reacted with 2,2′‐dihydroxybiphenyl ( 5 ) using p‐toluene sulfonic acid monohydrate (PTSA) as a catalyst to obtain 6‐α‐aminodibenzod f]1,3,2]dioxaphosphepin 6‐oxides ( 6 ) in good yield. It is a first report on the cyclizations of 4 with 5 . An antimicrobial activity of numbers of 6 is evaluated. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:2–8, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20244