Palladium-catalyzed regioselective reactions of silyl-substituted allylic carbonates and vinyl epoxide |
| |
| Affiliation: | 1. Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland;2. Department of Pharmacological Screening, Chair of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland;3. Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland;1. AstraZeneca, Centre de Recherches, Z.I. La Pompelle, B.P. 1050, Chemin de Vrilly, 51689 Reims, Cedex 2, France;2. AstraZeneca Pharmaceuticals, Oncology iMed, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom;1. Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City 110001, China;2. Key Laboratory of Gastric Cancer Molecular Pathology of Liaoning Province, 155 North Street, Heping District, Shenyang City 110001, China;1. Department of Inorganic Chemistry, Ivan Franko National University of Lviv, Kyryla i Mefodiya Str., 6, 79005, Lviv, Ukraine;2. Department of Inorganic Chemistry and Technology, Jožef Stefan Institute, Jamova 39, SI-1000, Ljubljana, Slovenia;3. Institute of Optoelectronics and Measuring Systems, Faculty of Electrical Engineering, Czestochowa University of Technology, 17 Armii Krajowej Str., 42-200, Czestochowa, Poland;4. Department of Solid State Physics, Lesya Ukrainka Eastern European National University, 13 Voli Ave., Lutsk, 43025, Ukraine;1. Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi, Osaka 558-8585, Japan;2. Advanced Research Institute for Natural Science & Technology, Osaka City University, Sugimoto, Sumiyoshi, Osaka 558-8585, Japan;1. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, PR China;2. College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China;3. Zhengjiang Jingxin Pharmaceutical Co., Ltd, Shaoxing, PR China |
| |
| Abstract: | Palladium-catalyzed reaction of α-substituted γ-trimethylsilylated allylic carbonates with carbonucleophiles took place regioselectively at the α-carbon. Reaction of formic acid took place at γ-carbon to afford allylic silanes. Methyl acetoacetate attacked regioselectively at 2-carbon of 1,2-epoxy-4-trimethylsilyl-3-butene. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
