Stereoselective synthesis of the hydroxy amino acid moiety of Al-77-B,a gastroprotective substance from Bacillus pumilus Al-77 |
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| Institution: | 1. School of Chemistry, Bangor University, Bangor, Gwynedd, LL57 2UW, UK;2. School of Natural Sciences, Bangor University, Bangor, Gwynedd, LL57 2UW, UK;3. School of Chemistry, Bristol University, Bristol, BS8 1TS, UK;1. Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA;2. Department of Internal Medicine, University of Iowa, Iowa City, IA 52242-1294, USA;3. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA |
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| Abstract: | The hydroxy amino acid moiety of Al-77-B (1) has been prepared as its protected form 2 from the (R)-glyceric acid derivative 3 in an efficiently stereoselective manner through the direct C-acylation using diphenyl phosphorazidate and the hydroxy-directed hydrogenation. |
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