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Heterocyclic synthesis via a tandem aza-Wittig reaction/heterocumulene-mediated annulation reaction. New methodology for the preparation of quinazoline derivatives.
Affiliation:1. Department of Fine Chem., (SNUT) Seoul National Univ. of Sci. and Tech., Seoul 01186, Republic of Korea;2. Department of Environ. Engineering, Seoul National Univ. of Sci. and Tech., Seoul 01186, Republic of Korea;3. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
Abstract:The aza-Wittig reaction of iminophosphoranes derived fromN-substituted o-azidobenzamides or 2-(o-azido) phenyl benzimidazolewith isocyanates, carbon dioxide or carbon disulphide, lead tofunctionalized 4(3H)-quinazolinones and benzimidazo [1,2-c]quinazolines respectively.
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