Amide bond isosteres: Imidazolines in pseudopeptide chemistry |
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| Affiliation: | 1. Chemistry Department, Faculty of Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine;2. Chemistry Department, Faculty of Science, Al-Azhar University, PO Box 1277, Gaza, Palestine;3. UMET, UMR CNRS N°8207, Université Lille 1—Sciences et Technologies, 59655 Villeneuve d’Ascq Cedex, France;4. Chemistry Department, Faculty of Applied Science, Alaqsa University, PO Box 4051, Gaza, Palestine;5. Medical Laboratory Sciences Department, Faculty of Health Science, Islamic University of Gaza, PO Box 108, Gaza Strip, Palestine;6. School of Chemistry, The University of Manchester, Brunswick Street, Manchester M13 9PL, United Kingdom;7. Manchester Institute of Biotechnology, School of Chemistry and EPS, The University of Manchester, Manchester M1 7DN, United Kingdom;1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536-0596, USA;2. Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509, USA;3. Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0596, USA;4. Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0093, USA |
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| Abstract: | The 2-imidazoline ring has been incorporated as an amide bondreplacement into pseudodipeptides, a pseudotripeptide, andpseudopentapeptide enkephalin analogues. |
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