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An approach to forskolin an efficient synthesis of a tricyclic lactone intermediate
Affiliation:1. Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan;2. Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677-1848, USA;3. Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA
Abstract:Tricyclic lactone 10, a potential intermediate for the synthesis of forskolin, was prepared from (±)-3-hydroxycyclocitral employing an intramolecular Michael addition as the key step.
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