A novel Diels-Alder approach to carbapenems |
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| Affiliation: | 1. Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa;2. Human Metabolomics, Faculty of Natural and Agricultural Science, North-West University, Private Bag X6001, Box 269, Potchefstroom 2531, South Africa;3. Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa |
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| Abstract: | An inverse electron demand hetero-Diels-Alder reaction between 2-acylaminomethylene-3-oxobutanoic acid derivatives (5) and ketene acetals (6) yields crystalline dihydropyrans, which are versatile intermediates in the synthesis of carbapenems. |
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