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Asymmetric reduction of oxime ethers. Distinction of anti and syn isomers leading to enantiomeric amines. |
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| Institution: | 1. Institution of Excellence, Vijnana Bhavana, Manasagangotri, University of Mysore, Mysuru, India;2. Department of Chemistry, Yuvaraja''s College, University of Mysore, Mysuru, India;3. Department of Studies in Physics, Manasagangotri, University of Mysore, Mysuru, India |
| Abstract: | Anti and syn ketoxime ethers were reduced with a chiral reducing agent prepared from (−)-norephedrine and 2 eq of BH3 to give S and R amines respectively in up to 92% ee. The preferred absolute configuration of the amine was depended on the geometry of the oxime ether. |
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