Total synthesis of the aglycone of the 8-methyl benzonaphthopyrone antibiotics,gilvocarcin M,virenomycin M,and albacarcin M |
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| Institution: | 1. College of Chemistry & Chemical Engineering, YangZhou University, YangZhou, Jiangsu 225002, People’s Republic of China;2. Guangling College, Yangzhou University, YangZhou, Jiangsu 225000, People’s Republic of China;3. Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam;4. Faculty of Natural Sciences, Duy Tan University, Da Nang 550000, Viet Nam;5. Department of Chemistry, Jouybar Branch, Islamic Azad University, 4776186131 Jouybar, Iran;1. Istanbul Medipol University International School of Medicine, REMER (Regenerative and Restorative Medicine Research Center), Kavacık Campus, Kavacık/Beykoz-ISTANBUL, Turkey;2. Winston Salem State University, 311 W.B. Atkinson Bldg., 601 MLK, Jr., Winston Salem, NC 27110, United States;3. 101 N Chestnut St. APT 3, Winston Salem, NC 27101, United States;4. 1524 Trinity Garden Circle, Clemmons, NC 27012, United States;5. Chemistry Department, Wake Forest University, Salem Hall, Box 7486, Winston-Salem, NC 27109, United States |
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| Abstract: | A short, convergent synthesis of the aglycone 5a of the 8-methyl benzonaphthopyrone antibiotics is described which utilizes as a key step a Suzuki biaryl coupling. |
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