Synthesis of a new tetracyclic system related to aptazapine (CGS 7525A) by one-pot double annelation |
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| Institution: | 1. Department of Environmental Sciences, Informatics and Statistics, University Ca'' Foscari, Venice, Italy;2. GreenDecision S.r.l., Venice, Italy;3. BASF SE, Dept. Material Physics, Ludwigshafen, Germany;4. National Research Centre for the Working Environment, Copenhagen, Denmark;5. Netherlands Organisation for Applied Scientific Research (TNO), The Hague, Netherlands;6. Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK |
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| Abstract: | Tandem annelation of the acetal 5 in acidic medium gave the intermediate tetracyclic amide 4, which was in turn reduced to 3b,4,6,7-tetrahydro-5-methyl-5H,9H-pyrazino- 2,1-c]pyrrolo1,2-a]1,4]benzodiazepine1. |
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