Enzymatic resolution of racemic lactones |
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| Affiliation: | 1. Medicinal Chemistry Laboratory, GVK Biosciences Pvt. Ltd., Plot No 28, IDA Nacharam, Hyderabad, 500076 Telangana, India;2. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, 500085 Telangana, India;1. Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. NMR Group, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India;1. School of Chemical Sciences, Mahatma Gandhi University, Kottayam 686 560, India;2. Department of Chemistry, St. Berchmans College, Changanacherry, 686 101, India;1. School of Chemistry, The University of Nottingham, University Park, Nottingham NG7 2RD, UK;2. Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, UK;1. Chulabhorn Research Institute, Bangkok, Thailand;2. Center of Excellence for Innovation in Drug Design and Discovery, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhya Road, Bangkok 10400, Thailand |
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| Abstract: | PPL, HLE or PLE enzymatic resolution of racemic γ, δ and ε-lactones gives optically active lactones (ee: 60 to 90%). |
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