The absolute configuration of kurospongin,a new furanoterpene from a marine sponge,Spongia sp |
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| Affiliation: | 1. Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, China;2. Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China;3. College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea;4. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325024, China;5. Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand;1. School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China;2. School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China;3. Jinan AISI Pharmaceutical Technology Co Ltd, Jinan 250104, PR China;4. Department of Urology, Institute of Urology, Gansu Nephro-Urological Clinical Center, Key Laboratory of Urological Diseases in Gansu Province, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, PR China;5. School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China;6. Department of Urology, The Second Hospital of Huangshi, Huangshi, Hubei 435000, PR China;1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China;2. Department of Pharmacy, Qilu Hospital of Shandong University, Jinan 250012, PR China;1. Department of Biotechnology, Dr. Babasaheb Ambedkar Marathwada University, Sub-Campus, Osmanabad, 413501, MS, India;2. Department of Microbiology, D. B. F. Dayanand College of Arts and Science, Solapur, MS, 4113002, India;3. Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Sub-Campus, Osmanabad, 413501, MS, India;4. Department of Zoology, Mizoram University, Tanhril, Aizawl, MZ, 796009, India;5. Laboratory of Applied Microbiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India;6. Late Pushpadevi Patil Arts and Science College, Risod, Washim, 444506, MS, India;1. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People’s Republic of China;2. Clinical Pharmacology Institute, School of Pharmacy, Nanchang University, Nanchang 330031, People’s Republic of China;1. Frontier Institute of Science and Technology, Xi''an Jiaotong University, Xi''an 710054, China;2. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | Kurospongin (1~), a new C21 furanoterpene having ichthyotoxic and feeding-deterrent properties has been isolated from a marine sponge,Spongia sp. The gross structure was deduced from the spectroscopic data and the absolute configuration by applying the Horeau method to a derivative prepared by the reaction of1~with ethylmagnesium bromide. |
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